Drug interactions
Ketorolac intranasal + Vancomycin
Severity: Moderate
Ketorolac intranasal and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is absorbed systemically after intranasal use and, like other NSAIDs, can reduce renal perfusion and clearance of vancomycin, which may raise levels and increase nephrotoxicity risk. This is described mainly in neonates.
What this interaction means in plain words
Ketorolac intranasal and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-induced reduction in renal blood flow and glomerular filtration, lowering vancomycin clearance and adding to nephrotoxic risk.
What to do
Monitor serum creatinine and vancomycin trough levels, and avoid prolonged concurrent use, especially in neonates or patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ketorolac intranasal and Vancomycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Ketorolac intranasal with Vancomycin?
MediHelp rates the interaction as moderate. Ketorolac intranasal and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac is absorbed systemically after intranasal use and, like other NSAIDs, can reduce renal perfusion and clearance of vancomycin, which may raise levels and increase nephrotoxicity risk. This is described mainly in neonates.
How serious is the interaction between Ketorolac intranasal and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and vancomycin trough levels, and avoid prolonged concurrent use, especially in neonates or patients with renal impairment.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
