Drug interactions
L-tryptophan + Linezolid
Severity: Major
L-tryptophan and Linezolid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tryptophan is the amino acid precursor of serotonin, and with an MAO inhibitor such as linezolid, serotonin can accumulate. Serotonin syndrome has been reported with MAOIs plus tryptophan.
What this interaction means in plain words
L-tryptophan and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Increased serotonin synthesis from tryptophan combined with reduced serotonin metabolism from MAO inhibition by linezolid.
What to do
Avoid the combination and stop tryptophan supplements before linezolid. If they must be given together, monitor for signs of serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take L-tryptophan with Linezolid?
MediHelp rates the interaction as major. L-tryptophan and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tryptophan is the amino acid precursor of serotonin, and with an MAO inhibitor such as linezolid, serotonin can accumulate. Serotonin syndrome has been reported with MAOIs plus tryptophan.
How serious is the interaction between L-tryptophan and Linezolid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and stop tryptophan supplements before linezolid. If they must be given together, monitor for signs of serotonin toxicity.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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