Drug interactions
L-tryptophan + Naratriptan
Severity: Minor
L-tryptophan and Naratriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
L-tryptophan is a serotonin precursor and can increase serotonin synthesis. With a triptan, there is a theoretical risk of serotonin toxicity. Clinical reports are scarce.
What this interaction means in plain words
L-tryptophan and Naratriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Increased serotonin synthesis from tryptophan combined with 5-HT1B/1D agonism.
What to do
Ask about supplement use and counsel on serotonin syndrome symptoms. Avoid high-dose tryptophan with triptans if possible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take L-tryptophan with Naratriptan?
MediHelp rates the interaction as minor. L-tryptophan and Naratriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. L-tryptophan is a serotonin precursor and can increase serotonin synthesis. With a triptan, there is a theoretical risk of serotonin toxicity. Clinical reports are scarce.
How serious is the interaction between L-tryptophan and Naratriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask about supplement use and counsel on serotonin syndrome symptoms. Avoid high-dose tryptophan with triptans if possible.
What other medicines interact with Naratriptan?
MediHelp also lists interactions of Naratriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Naratriptan page.
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