Drug interactions
L-tryptophan + Tranylcypromine
Severity: Major
L-tryptophan and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tryptophan is the precursor of serotonin, and with an MAO inhibitor that blocks serotonin breakdown it can cause serotonin syndrome. Features include agitation, hyperthermia, tremor, clonus and autonomic instability.
What this interaction means in plain words
L-tryptophan and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Increased serotonin synthesis from tryptophan combined with blocked serotonin degradation through MAO inhibition.
What to do
Avoid combining tryptophan supplements with tranylcypromine. If exposure occurs, stop tryptophan and monitor for serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take L-tryptophan with Tranylcypromine?
MediHelp rates the interaction as major. L-tryptophan and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tryptophan is the precursor of serotonin, and with an MAO inhibitor that blocks serotonin breakdown it can cause serotonin syndrome. Features include agitation, hyperthermia, tremor, clonus and autonomic instability.
How serious is the interaction between L-tryptophan and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining tryptophan supplements with tranylcypromine. If exposure occurs, stop tryptophan and monitor for serotonin toxicity.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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