Drug interactions
Lamivudine + Tafenoquine
Severity: Moderate
Lamivudine and Tafenoquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lamivudine is cleared largely by renal tubular secretion through organic cation transporters. Tafenoquine inhibits OCT2 and MATE transporters in vitro and may raise lamivudine concentrations, although the clinical effect is probably modest.
What this interaction means in plain words
Lamivudine and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lamivudine belongs to Anti Virals; Tafenoquine belongs to Anti Parasitic.
Why it happens
Tafenoquine inhibits OCT2 and MATE transporters, reducing renal tubular secretion of lamivudine.
What to do
Monitor for lamivudine adverse effects such as cytopenias and gastrointestinal symptoms. Consider a dose reduction in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamivudine
Other interactions of Tafenoquine
- Dofetilide + Tafenoquine Major
- Alogliptin-metformin + Tafenoquine Moderate
- Amantadine + Tafenoquine Moderate
- Amiloride + Tafenoquine Moderate
- Canagliflozin-metformin + Tafenoquine Moderate
- Cimetidine + Tafenoquine Moderate
Frequently asked questions
Can I take Lamivudine with Tafenoquine?
MediHelp rates the interaction as moderate. Lamivudine and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lamivudine is cleared largely by renal tubular secretion through organic cation transporters. Tafenoquine inhibits OCT2 and MATE transporters in vitro and may raise lamivudine concentrations, although the clinical effect is probably modest.
How serious is the interaction between Lamivudine and Tafenoquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lamivudine adverse effects such as cytopenias and gastrointestinal symptoms. Consider a dose reduction in patients with renal impairment.
What other medicines interact with Lamivudine?
MediHelp also lists interactions of Lamivudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Atidarsagene autotemcel, Betibeglogene autotemcel. The full list is on the Lamivudine page.
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