Drug interactions
Dofetilide + Tafenoquine
Severity: Major
Dofetilide and Tafenoquine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafenoquine inhibits renal OCT2 and MATE transporters, which can raise dofetilide levels. Elevated dofetilide risks QT prolongation and torsades de pointes.
What this interaction means in plain words
Dofetilide and Tafenoquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dofetilide belongs to Cardiovascular; Tafenoquine belongs to Anti Parasitic.
Why it happens
Inhibition of OCT2/MATE-mediated renal secretion of dofetilide.
What to do
Avoid the combination; use another antimalarial regimen if feasible. If unavoidable, monitor QTc and renal function closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tafenoquine
- Alogliptin-metformin + Tafenoquine Moderate
- Amantadine + Tafenoquine Moderate
- Amiloride + Tafenoquine Moderate
- Canagliflozin-metformin + Tafenoquine Moderate
- Cimetidine + Tafenoquine Moderate
- Cisplatin + Tafenoquine Moderate
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Tafenoquine?
MediHelp rates the interaction as major. Dofetilide and Tafenoquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tafenoquine inhibits renal OCT2 and MATE transporters, which can raise dofetilide levels. Elevated dofetilide risks QT prolongation and torsades de pointes.
How serious is the interaction between Dofetilide and Tafenoquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use another antimalarial regimen if feasible. If unavoidable, monitor QTc and renal function closely.
What other medicines interact with Tafenoquine?
MediHelp also lists interactions of Tafenoquine with, for example, Alogliptin-metformin, Amantadine, Amiloride. The full list is on the Tafenoquine page.
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