Drug interactions
Canagliflozin-metformin + Tafenoquine
Severity: Moderate
Canagliflozin-metformin and Tafenoquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafenoquine inhibits OCT2 and MATE transporters in vitro, which handle renal secretion of metformin. Coadministration may raise metformin concentrations and the risk of dose-related adverse effects including lactic acidosis.
What this interaction means in plain words
Canagliflozin-metformin and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Tafenoquine belongs to Anti Parasitic.
Why it happens
Inhibition of renal OCT2 and MATE transporters decreases tubular secretion of metformin.
What to do
Monitor for metformin adverse effects and renal function during tafenoquine use, which is typically a short course. Reduce the metformin dose if toxicity or reduced renal function occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Canagliflozin-metformin and Tafenoquine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Canagliflozin-metformin
Other interactions of Tafenoquine
- Dofetilide + Tafenoquine Major
- Alogliptin-metformin + Tafenoquine Moderate
- Amantadine + Tafenoquine Moderate
- Amiloride + Tafenoquine Moderate
- Cimetidine + Tafenoquine Moderate
- Cisplatin + Tafenoquine Moderate
Frequently asked questions
Can I take Canagliflozin-metformin with Tafenoquine?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tafenoquine inhibits OCT2 and MATE transporters in vitro, which handle renal secretion of metformin. Coadministration may raise metformin concentrations and the risk of dose-related adverse effects including lactic acidosis.
How serious is the interaction between Canagliflozin-metformin and Tafenoquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for metformin adverse effects and renal function during tafenoquine use, which is typically a short course. Reduce the metformin dose if toxicity or reduced renal function occurs.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
