Drug interactions
Lamivudine + Trilaciclib
Severity: Minor
Lamivudine and Trilaciclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilaciclib inhibits renal cation transporters involved in lamivudine secretion, so lamivudine exposure is expected to rise rather than fall. The clinical significance is likely small because trilaciclib is given briefly and lamivudine has a wide margin of safety.
What this interaction means in plain words
Lamivudine and Trilaciclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lamivudine belongs to Anti Virals; Trilaciclib belongs to Oncology.
Why it happens
Trilaciclib inhibits OCT2, MATE1 and MATE2-K, reducing renal tubular secretion of lamivudine.
What to do
No routine dose change is needed; monitor for lamivudine adverse effects in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lamivudine
Other interactions of Trilaciclib
Frequently asked questions
Can I take Lamivudine with Trilaciclib?
MediHelp rates the interaction as minor. Lamivudine and Trilaciclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trilaciclib inhibits renal cation transporters involved in lamivudine secretion, so lamivudine exposure is expected to rise rather than fall. The clinical significance is likely small because trilaciclib is given briefly and lamivudine has a wide margin of safety.
How serious is the interaction between Lamivudine and Trilaciclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for lamivudine adverse effects in patients with renal impairment.
What other medicines interact with Lamivudine?
MediHelp also lists interactions of Lamivudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Atidarsagene autotemcel, Betibeglogene autotemcel. The full list is on the Lamivudine page.
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