Drug interactions
Lamotrigine + Levetiracetam
Severity: Minor
Lamotrigine and Levetiracetam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both antiseizure drugs can cause somnolence, dizziness and fatigue, so side effects may be additive. The combination is commonly used and usually tolerated.
What this interaction means in plain words
Lamotrigine and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lamotrigine belongs to Central Nervous System; Levetiracetam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects (pharmacodynamic).
What to do
Titrate slowly and monitor for sedation and ataxia. Advise caution when driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lamotrigine
Other interactions of Levetiracetam
Frequently asked questions
Can I take Lamotrigine with Levetiracetam?
MediHelp rates the interaction as minor. Lamotrigine and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both antiseizure drugs can cause somnolence, dizziness and fatigue, so side effects may be additive. The combination is commonly used and usually tolerated.
How serious is the interaction between Lamotrigine and Levetiracetam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate slowly and monitor for sedation and ataxia. Advise caution when driving.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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