Drug interactions
Lamotrigine + Methohexital
Severity: Moderate
Lamotrigine and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a barbiturate anesthetic causing profound CNS depression, and lamotrigine may add to sedation. The combination may prolong recovery or deepen sedation.
What this interaction means in plain words
Lamotrigine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lamotrigine belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Titrate methohexital to effect with continuous monitoring of sedation and respiration. Continue lamotrigine as prescribed and tell the anesthesia team.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Other interactions of Methohexital
Frequently asked questions
Can I take Lamotrigine with Methohexital?
MediHelp rates the interaction as moderate. Lamotrigine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a barbiturate anesthetic causing profound CNS depression, and lamotrigine may add to sedation. The combination may prolong recovery or deepen sedation.
How serious is the interaction between Lamotrigine and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital to effect with continuous monitoring of sedation and respiration. Continue lamotrigine as prescribed and tell the anesthesia team.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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