Drug interactions
Lamotrigine + Sertraline
Severity: Minor
Lamotrigine and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline may modestly raise lamotrigine concentrations in some patients, as isolated reports describe, and both drugs can cause CNS effects such as dizziness and somnolence. The interaction is usually of limited clinical significance.
What this interaction means in plain words
Lamotrigine and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lamotrigine belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Possible modest inhibition of lamotrigine glucuronidation by sertraline, plus additive CNS effects; the mechanism is not firmly established.
What to do
No dose change is routinely needed. Monitor for lamotrigine adverse effects such as dizziness, ataxia or rash when starting or stopping sertraline.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Lamotrigine
Frequently asked questions
Can I take Lamotrigine with Sertraline?
MediHelp rates the interaction as minor. Lamotrigine and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sertraline may modestly raise lamotrigine concentrations in some patients, as isolated reports describe, and both drugs can cause CNS effects such as dizziness and somnolence. The interaction is usually of limited clinical significance.
How serious is the interaction between Lamotrigine and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Monitor for lamotrigine adverse effects such as dizziness, ataxia or rash when starting or stopping sertraline.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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