Drug interactions
Lansoprazole + Lemborexant
Severity: Minor
Lansoprazole and Lemborexant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lansoprazole may modestly increase lemborexant exposure through weak CYP3A4 inhibition. This could increase next-day somnolence and impairment.
What this interaction means in plain words
Lansoprazole and Lemborexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Lemborexant belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition reduces lemborexant clearance.
What to do
Watch for daytime drowsiness and reduce the lemborexant dose according to labeling if weak CYP3A4 inhibitors are used and it is not tolerated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Lansoprazole with Lemborexant?
MediHelp rates the interaction as minor. Lansoprazole and Lemborexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lansoprazole may modestly increase lemborexant exposure through weak CYP3A4 inhibition. This could increase next-day somnolence and impairment.
How serious is the interaction between Lansoprazole and Lemborexant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for daytime drowsiness and reduce the lemborexant dose according to labeling if weak CYP3A4 inhibitors are used and it is not tolerated.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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