Drug interactions
Lansoprazole + Lenacapavir
Severity: Minor
Lansoprazole and Lenacapavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor, so lansoprazole exposure may rise somewhat. Because of the long half-life of subcutaneous lenacapavir, this effect can persist for months, but the clinical significance is expected to be low.
What this interaction means in plain words
Lansoprazole and Lenacapavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Lenacapavir belongs to Anti Virals.
Why it happens
Lenacapavir inhibits CYP3A4, decreasing lansoprazole metabolism.
What to do
No dose change is routinely needed; be aware that the effect can persist after the last injection.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lansoprazole with Lenacapavir?
MediHelp rates the interaction as minor. Lansoprazole and Lenacapavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lenacapavir is a moderate CYP3A inhibitor, so lansoprazole exposure may rise somewhat. Because of the long half-life of subcutaneous lenacapavir, this effect can persist for months, but the clinical significance is expected to be low.
How serious is the interaction between Lansoprazole and Lenacapavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; be aware that the effect can persist after the last injection.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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