Drug interactions
Lansoprazole + Mitotane
Severity: Moderate
Lansoprazole and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and can substantially lower lansoprazole concentrations. This may reduce acid suppression and effectiveness for reflux or ulcer therapy.
What this interaction means in plain words
Lansoprazole and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lansoprazole belongs to Gastrointestinal Tract; Mitotane belongs to Oncology.
Why it happens
Mitotane induces CYP3A4, increasing lansoprazole clearance.
What to do
Monitor symptom control and consider a higher lansoprazole dose or an alternative acid suppressant if response is inadequate. Induction may persist for weeks after mitotane stops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Lansoprazole with Mitotane?
MediHelp rates the interaction as moderate. Lansoprazole and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and can substantially lower lansoprazole concentrations. This may reduce acid suppression and effectiveness for reflux or ulcer therapy.
How serious is the interaction between Lansoprazole and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and consider a higher lansoprazole dose or an alternative acid suppressant if response is inadequate. Induction may persist for weeks after mitotane stops.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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