Drug interactions
Lansoprazole + Neratinib
Severity: Major
Lansoprazole and Neratinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Neratinib absorption falls in a higher gastric pH, and PPIs markedly reduce its exposure. This may reduce its effectiveness in breast cancer.
What this interaction means in plain words
Lansoprazole and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lansoprazole belongs to Gastrointestinal Tract; Neratinib belongs to Oncology.
Why it happens
Increased gastric pH reduces neratinib solubility and absorption.
What to do
Avoid PPIs with neratinib. Use an H2 blocker with neratinib given at least 2 hours before or 10 hours after it, or an antacid separated by 3 hours.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Neratinib
- Amiodarone + Neratinib Major
- Amobarbital + Neratinib Major
- Aprepitant + Neratinib Major
- Armodafinil + Neratinib Major
- Bosentan + Neratinib Major
- Carbamazepine + Neratinib Major
Frequently asked questions
Can I take Lansoprazole with Neratinib?
MediHelp rates the interaction as major. Lansoprazole and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Neratinib absorption falls in a higher gastric pH, and PPIs markedly reduce its exposure. This may reduce its effectiveness in breast cancer.
How serious is the interaction between Lansoprazole and Neratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with neratinib. Use an H2 blocker with neratinib given at least 2 hours before or 10 hours after it, or an antacid separated by 3 hours.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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