Drug interactions
Lansoprazole + Pexidartinib
Severity: Major
Lansoprazole and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib exposure is reduced by acid-suppressing drugs, particularly PPIs, which may lower its efficacy in tenosynovial giant cell tumour.
What this interaction means in plain words
Lansoprazole and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lansoprazole belongs to Gastrointestinal Tract; Pexidartinib belongs to Oncology.
Why it happens
Elevated gastric pH lowers pexidartinib solubility and absorption.
What to do
Avoid PPIs. If needed, give pexidartinib 2 hours before or after an antacid, or at least 2 hours before or 10 hours after an H2 blocker.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Pexidartinib
Frequently asked questions
Can I take Lansoprazole with Pexidartinib?
MediHelp rates the interaction as major. Lansoprazole and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib exposure is reduced by acid-suppressing drugs, particularly PPIs, which may lower its efficacy in tenosynovial giant cell tumour.
How serious is the interaction between Lansoprazole and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs. If needed, give pexidartinib 2 hours before or after an antacid, or at least 2 hours before or 10 hours after an H2 blocker.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
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