Drug interactions
Lansoprazole + Ritonavir
Severity: Minor
Lansoprazole and Ritonavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits CYP3A4 and may raise lansoprazole concentrations. Lansoprazole has a wide safety margin, so the increase is rarely important, though ritonavir also induces CYP2C19 and may offset this.
What this interaction means in plain words
Lansoprazole and Ritonavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir inhibits CYP3A4-mediated lansoprazole metabolism and may also induce CYP2C19.
What to do
No adjustment is usually needed; monitor tolerance and acid control.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Lansoprazole with Ritonavir?
MediHelp rates the interaction as minor. Lansoprazole and Ritonavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ritonavir inhibits CYP3A4 and may raise lansoprazole concentrations. Lansoprazole has a wide safety margin, so the increase is rarely important, though ritonavir also induces CYP2C19 and may offset this.
How serious is the interaction between Lansoprazole and Ritonavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is usually needed; monitor tolerance and acid control.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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