Drug interactions
Lansoprazole + Voxelotor
Severity: Minor
Lansoprazole and Voxelotor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and may increase lansoprazole exposure. Lansoprazole has a wide safety margin and a second CYP2C19 pathway, so the effect is unlikely to matter clinically.
What this interaction means in plain words
Lansoprazole and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor weakly inhibits CYP3A4, which contributes to lansoprazole metabolism.
What to do
No adjustment is routinely required; monitor for PPI adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Lansoprazole with Voxelotor?
MediHelp rates the interaction as minor. Lansoprazole and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voxelotor inhibits CYP3A4 and may increase lansoprazole exposure. Lansoprazole has a wide safety margin and a second CYP2C19 pathway, so the effect is unlikely to matter clinically.
How serious is the interaction between Lansoprazole and Voxelotor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is routinely required; monitor for PPI adverse effects.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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