Drug interactions
Lapatinib + Lofepramine
Severity: Moderate
Lapatinib and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may prolong the QT interval, potentially increasing risk of ventricular arrhythmias, especially with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Lapatinib and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation via cardiac ion channel effects.
What to do
Obtain a baseline and follow-up ECG and correct potassium and magnesium. Consider an alternative antidepressant if QTc lengthens markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Lofepramine?
MediHelp rates the interaction as moderate. Lapatinib and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may prolong the QT interval, potentially increasing risk of ventricular arrhythmias, especially with electrolyte disturbances or cardiac disease.
How serious is the interaction between Lapatinib and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline and follow-up ECG and correct potassium and magnesium. Consider an alternative antidepressant if QTc lengthens markedly.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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