Drug interactions
Lapatinib + Miconazole vaginal
Severity: Minor
Lapatinib and Miconazole vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miconazole is a CYP3A4 inhibitor, but vaginal use gives low systemic exposure. Clinically meaningful rises in lapatinib concentrations are therefore unlikely with short courses, although more extensive absorption cannot be excluded.
What this interaction means in plain words
Lapatinib and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 inhibition by systemically absorbed miconazole, limited by low vaginal absorption.
What to do
No routine adjustment is needed; watch for lapatinib adverse effects such as diarrhea, rash and QT changes if prolonged or repeated miconazole courses are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Miconazole vaginal?
MediHelp rates the interaction as minor. Lapatinib and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Miconazole is a CYP3A4 inhibitor, but vaginal use gives low systemic exposure. Clinically meaningful rises in lapatinib concentrations are therefore unlikely with short courses, although more extensive absorption cannot be excluded.
How serious is the interaction between Lapatinib and Miconazole vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for lapatinib adverse effects such as diarrhea, rash and QT changes if prolonged or repeated miconazole courses are used.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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