Drug interactions
Lapatinib + Nitrendipine
Severity: Minor
Lapatinib and Nitrendipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrendipine is extensively metabolized by CYP3A4, so lapatinib may moderately raise its exposure. This may cause excessive blood pressure reduction, flushing and edema.
What this interaction means in plain words
Lapatinib and Nitrendipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Lapatinib weakly inhibits CYP3A4, reducing nitrendipine clearance.
What to do
Monitor blood pressure after lapatinib is started. Lower the nitrendipine dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Nitrendipine?
MediHelp rates the interaction as minor. Lapatinib and Nitrendipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nitrendipine is extensively metabolized by CYP3A4, so lapatinib may moderately raise its exposure. This may cause excessive blood pressure reduction, flushing and edema.
How serious is the interaction between Lapatinib and Nitrendipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after lapatinib is started. Lower the nitrendipine dose if hypotension occurs.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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