Drug interactions
Lapatinib + Octreotide
Severity: Moderate
Lapatinib and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib prolongs the QTc interval and octreotide has been associated with QT changes and bradycardia. Together they may increase the risk of serious ventricular arrhythmia, especially in susceptible patients.
What this interaction means in plain words
Lapatinib and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Octreotide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization (QTc prolongation).
What to do
Check a baseline ECG and monitor QTc periodically. Keep potassium and magnesium within normal range and avoid other QT-prolonging agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Octreotide?
MediHelp rates the interaction as moderate. Lapatinib and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib prolongs the QTc interval and octreotide has been associated with QT changes and bradycardia. Together they may increase the risk of serious ventricular arrhythmia, especially in susceptible patients.
How serious is the interaction between Lapatinib and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor QTc periodically. Keep potassium and magnesium within normal range and avoid other QT-prolonging agents.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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