Drug interactions
Lapatinib + Olodaterol inhaled
Severity: Moderate
Lapatinib and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib can prolong the QT interval, and beta2-agonists such as olodaterol can cause tachycardia, hypokalemia and QT effects. Together they may modestly increase the risk of arrhythmia, although inhaled systemic exposure is low.
What this interaction means in plain words
Lapatinib and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and beta2-mediated hypokalemia.
What to do
Monitor ECG and keep potassium and magnesium within normal range, particularly in patients with cardiac disease or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Lapatinib and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib can prolong the QT interval, and beta2-agonists such as olodaterol can cause tachycardia, hypokalemia and QT effects. Together they may modestly increase the risk of arrhythmia, although inhaled systemic exposure is low.
How serious is the interaction between Lapatinib and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and keep potassium and magnesium within normal range, particularly in patients with cardiac disease or other QT-prolonging drugs.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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