Drug interactions
Lapatinib + Paclitaxel protein bound
Severity: Moderate
Lapatinib and Paclitaxel protein bound: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits P-gp and may inhibit CYP2C8, which could raise paclitaxel exposure. This may increase neutropenia and neuropathy, and both drugs can cause diarrhea or other toxicity.
What this interaction means in plain words
Lapatinib and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lapatinib inhibits P-gp efflux and possibly CYP2C8 metabolism of paclitaxel.
What to do
Monitor blood counts and neuropathy, and reduce the paclitaxel dose or delay treatment if severe toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Paclitaxel protein bound?
MediHelp rates the interaction as moderate. Lapatinib and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits P-gp and may inhibit CYP2C8, which could raise paclitaxel exposure. This may increase neutropenia and neuropathy, and both drugs can cause diarrhea or other toxicity.
How serious is the interaction between Lapatinib and Paclitaxel protein bound?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy, and reduce the paclitaxel dose or delay treatment if severe toxicity occurs.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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