Drug interactions
Lapatinib + Parecoxib
Severity: Minor
Lapatinib and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is converted to valdecoxib, which is cleared partly by CYP3A4 and CYP2C9. Lapatinib may modestly raise valdecoxib levels, with a small increase in NSAID adverse effects.
What this interaction means in plain words
Lapatinib and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Lapatinib weakly inhibits CYP3A4, reducing valdecoxib metabolism.
What to do
Use the lowest effective parecoxib dose for the shortest duration. Monitor for gastrointestinal, renal and blood pressure effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Parecoxib?
MediHelp rates the interaction as minor. Lapatinib and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Parecoxib is converted to valdecoxib, which is cleared partly by CYP3A4 and CYP2C9. Lapatinib may modestly raise valdecoxib levels, with a small increase in NSAID adverse effects.
How serious is the interaction between Lapatinib and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective parecoxib dose for the shortest duration. Monitor for gastrointestinal, renal and blood pressure effects.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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