Drug interactions
Lapatinib + Pentobarbital
Severity: Moderate
Lapatinib and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital induces CYP3A4 and may reduce lapatinib concentrations, risking reduced efficacy. Additive sedation is also possible but is not a recognized lapatinib effect.
What this interaction means in plain words
Lapatinib and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by pentobarbital increases lapatinib clearance.
What to do
Avoid if possible and use a non-inducing sedative; otherwise monitor tumor response and consider the lapatinib dose increase recommended for strong inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Pentobarbital?
MediHelp rates the interaction as moderate. Lapatinib and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital induces CYP3A4 and may reduce lapatinib concentrations, risking reduced efficacy. Additive sedation is also possible but is not a recognized lapatinib effect.
How serious is the interaction between Lapatinib and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use a non-inducing sedative; otherwise monitor tumor response and consider the lapatinib dose increase recommended for strong inducers.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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