Drug interactions
Lapatinib + Romidepsin
Severity: Major
Lapatinib and Romidepsin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents prolong QT, and lapatinib may raise romidepsin exposure by inhibiting CYP3A4 and P-gp. The combination increases the risk of ventricular arrhythmia and romidepsin toxicity.
What this interaction means in plain words
Lapatinib and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation plus lapatinib inhibition of CYP3A4 and P-gp affecting romidepsin clearance.
What to do
Check ECG and potassium and magnesium before and during treatment, and avoid the combination in patients with QT prolongation. Monitor closely for romidepsin toxicity such as myelosuppression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Romidepsin?
MediHelp rates the interaction as major. Lapatinib and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents prolong QT, and lapatinib may raise romidepsin exposure by inhibiting CYP3A4 and P-gp. The combination increases the risk of ventricular arrhythmia and romidepsin toxicity.
How serious is the interaction between Lapatinib and Romidepsin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and potassium and magnesium before and during treatment, and avoid the combination in patients with QT prolongation. Monitor closely for romidepsin toxicity such as myelosuppression.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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