Drug interactions
Lapatinib + Sofosbuvir / velpatasvir
Severity: Moderate
Lapatinib and Sofosbuvir / velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits the efflux transporter BCRP, and lapatinib is a BCRP substrate. Systemic exposure to lapatinib may therefore rise, increasing the risk of diarrhea, rash and hepatotoxicity.
What this interaction means in plain words
Lapatinib and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Velpatasvir inhibits BCRP-mediated efflux, which may increase lapatinib absorption and reduce its clearance.
What to do
Monitor for lapatinib adverse effects such as diarrhea, rash and liver enzyme elevation during co-therapy. Consider lapatinib dose reduction if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as moderate. Lapatinib and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir inhibits the efflux transporter BCRP, and lapatinib is a BCRP substrate. Systemic exposure to lapatinib may therefore rise, increasing the risk of diarrhea, rash and hepatotoxicity.
How serious is the interaction between Lapatinib and Sofosbuvir / velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lapatinib adverse effects such as diarrhea, rash and liver enzyme elevation during co-therapy. Consider lapatinib dose reduction if toxicity emerges.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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