Drug interactions
Lapatinib + Teniposide
Severity: Moderate
Lapatinib and Teniposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits P-glycoprotein, and teniposide is a P-gp substrate. Teniposide exposure may increase, worsening myelosuppression and mucositis.
What this interaction means in plain words
Lapatinib and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lapatinib inhibits P-gp efflux, potentially increasing teniposide absorption and reducing its elimination.
What to do
Monitor blood counts and mucosal toxicity closely. Reduce the teniposide dose if marked myelosuppression occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Teniposide?
MediHelp rates the interaction as moderate. Lapatinib and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits P-glycoprotein, and teniposide is a P-gp substrate. Teniposide exposure may increase, worsening myelosuppression and mucositis.
How serious is the interaction between Lapatinib and Teniposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and mucosal toxicity closely. Reduce the teniposide dose if marked myelosuppression occurs.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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