Drug interactions
Lapatinib + Tezacaftor
Severity: Minor
Lapatinib and Tezacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tezacaftor is a CYP3A4 substrate, and lapatinib may modestly raise its concentrations. The clinical effect is probably small, with possible increases in tezacaftor adverse effects.
What this interaction means in plain words
Lapatinib and Tezacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Lapatinib weakly inhibits CYP3A4, reducing tezacaftor metabolism.
What to do
Monitor for tezacaftor adverse effects such as headache and liver enzyme elevation. No empirical dose change is usually needed with a weak inhibitor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Tezacaftor?
MediHelp rates the interaction as minor. Lapatinib and Tezacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tezacaftor is a CYP3A4 substrate, and lapatinib may modestly raise its concentrations. The clinical effect is probably small, with possible increases in tezacaftor adverse effects.
How serious is the interaction between Lapatinib and Tezacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tezacaftor adverse effects such as headache and liver enzyme elevation. No empirical dose change is usually needed with a weak inhibitor.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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