Drug interactions
Lapatinib + Triamcinolone acetonide injectable
Severity: Moderate
Lapatinib and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamcinolone is cleared by CYP3A4, so lapatinib may raise systemic corticosteroid levels. This can lead to Cushingoid effects and adrenal suppression, mainly with repeated or high-dose injections.
What this interaction means in plain words
Lapatinib and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lapatinib inhibits CYP3A4 and reduces triamcinolone metabolism.
What to do
Monitor for corticosteroid excess such as hyperglycemia, fluid retention and Cushingoid features. Use the lowest effective triamcinolone dose and extend the interval between injections.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Lapatinib and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triamcinolone is cleared by CYP3A4, so lapatinib may raise systemic corticosteroid levels. This can lead to Cushingoid effects and adrenal suppression, mainly with repeated or high-dose injections.
How serious is the interaction between Lapatinib and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess such as hyperglycemia, fluid retention and Cushingoid features. Use the lowest effective triamcinolone dose and extend the interval between injections.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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