Drug interactions
Lapatinib + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Lapatinib and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib prolongs the QT interval and vilanterol, a beta-agonist, may add to cardiac effects. Systemic exposure from the inhaler is low, so the risk is modest.
What this interaction means in plain words
Lapatinib and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and adrenergic cardiovascular effects.
What to do
Monitor ECG and electrolytes in patients with cardiac risk factors. Use the inhaler at the labeled dose only.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Lapatinib and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib prolongs the QT interval and vilanterol, a beta-agonist, may add to cardiac effects. Systemic exposure from the inhaler is low, so the risk is modest.
How serious is the interaction between Lapatinib and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes in patients with cardiac risk factors. Use the inhaler at the labeled dose only.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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