Drug interactions
Lapatinib + Vincristine liposomal
Severity: Moderate
Lapatinib and Vincristine liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits P-glycoprotein, and vincristine is a P-gp and CYP3A4 substrate. Vincristine exposure may increase, worsening neurotoxicity and constipation.
What this interaction means in plain words
Lapatinib and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lapatinib inhibits P-gp efflux and CYP3A4, potentially increasing vincristine exposure.
What to do
Monitor for peripheral neuropathy, constipation and ileus. Reduce or delay the vincristine dose if neurotoxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Vincristine liposomal?
MediHelp rates the interaction as moderate. Lapatinib and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits P-glycoprotein, and vincristine is a P-gp and CYP3A4 substrate. Vincristine exposure may increase, worsening neurotoxicity and constipation.
How serious is the interaction between Lapatinib and Vincristine liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for peripheral neuropathy, constipation and ileus. Reduce or delay the vincristine dose if neurotoxicity appears.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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