Drug interactions
Lapatinib + Zaleplon
Severity: Minor
Lapatinib and Zaleplon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4 and could modestly raise zaleplon concentrations. Because CYP3A4 is a secondary route for zaleplon, the effect is expected to be small, though sedation may increase.
What this interaction means in plain words
Lapatinib and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lapatinib belongs to Oncology; Zaleplon belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 by lapatinib reduces secondary oxidative clearance of zaleplon.
What to do
No dose adjustment is usually required; monitor for excess sedation and counsel on driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Zaleplon?
MediHelp rates the interaction as minor. Lapatinib and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lapatinib inhibits CYP3A4 and could modestly raise zaleplon concentrations. Because CYP3A4 is a secondary route for zaleplon, the effect is expected to be small, though sedation may increase.
How serious is the interaction between Lapatinib and Zaleplon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; monitor for excess sedation and counsel on driving.
What other medicines interact with Zaleplon?
MediHelp also lists interactions of Zaleplon with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Brexanolone. The full list is on the Zaleplon page.
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