Drug interactions
Lapatinib + Zolpidem
Severity: Minor
Lapatinib and Zolpidem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib is a weak CYP3A4 inhibitor and could modestly raise zolpidem levels, with a small increase in sedation. The effect is expected to be limited.
What this interaction means in plain words
Lapatinib and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lapatinib belongs to Oncology; Zolpidem belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 by lapatinib may reduce zolpidem clearance.
What to do
No routine dose change is needed; counsel patients to report excessive daytime drowsiness and reduce the zolpidem dose if it occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zolpidem
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Zolpidem?
MediHelp rates the interaction as minor. Lapatinib and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lapatinib is a weak CYP3A4 inhibitor and could modestly raise zolpidem levels, with a small increase in sedation. The effect is expected to be limited.
How serious is the interaction between Lapatinib and Zolpidem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; counsel patients to report excessive daytime drowsiness and reduce the zolpidem dose if it occurs.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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