Drug interactions
Larotrectinib + Levonorgestrel
Severity: Minor
Larotrectinib and Levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A rise in levonorgestrel exposure via weak CYP3A4 inhibition by larotrectinib is theoretical and likely negligible. Systemic exposure from an intrauterine system is low.
What this interaction means in plain words
Larotrectinib and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Levonorgestrel belongs to Endocrine.
Why it happens
Possible weak CYP3A4 inhibition; not well established.
What to do
No routine adjustment is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levonorgestrel
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Levonorgestrel?
MediHelp rates the interaction as minor. Larotrectinib and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. A rise in levonorgestrel exposure via weak CYP3A4 inhibition by larotrectinib is theoretical and likely negligible. Systemic exposure from an intrauterine system is low.
How serious is the interaction between Larotrectinib and Levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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