Drug interactions
Larotrectinib + Lorlatinib
Severity: Moderate
Larotrectinib and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A4 and may reduce larotrectinib concentrations, potentially reducing antitumor activity.
What this interaction means in plain words
Larotrectinib and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Larotrectinib belongs to Oncology; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, accelerating larotrectinib metabolism.
What to do
Monitor tumor response and consider an alternative to lorlatinib. If unavoidable, dose adjustment of larotrectinib per labeling for inducers may be needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Lorlatinib?
MediHelp rates the interaction as moderate. Larotrectinib and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib induces CYP3A4 and may reduce larotrectinib concentrations, potentially reducing antitumor activity.
How serious is the interaction between Larotrectinib and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and consider an alternative to lorlatinib. If unavoidable, dose adjustment of larotrectinib per labeling for inducers may be needed.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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