Drug interactions
Larotrectinib + Netupitant-palonosetron
Severity: Moderate
Larotrectinib and Netupitant-palonosetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is metabolized by CYP3A4, so netupitant as a moderate inhibitor may increase its exposure. This raises the possibility of more adverse effects such as dizziness, liver enzyme elevation and neurotoxicity.
What this interaction means in plain words
Larotrectinib and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Larotrectinib belongs to Oncology; Netupitant-palonosetron belongs to Gastrointestinal Tract.
Why it happens
Netupitant inhibits CYP3A4-mediated larotrectinib metabolism.
What to do
Monitor for larotrectinib toxicity and liver tests; reduce the larotrectinib dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Netupitant-palonosetron?
MediHelp rates the interaction as moderate. Larotrectinib and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Larotrectinib is metabolized by CYP3A4, so netupitant as a moderate inhibitor may increase its exposure. This raises the possibility of more adverse effects such as dizziness, liver enzyme elevation and neurotoxicity.
How serious is the interaction between Larotrectinib and Netupitant-palonosetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for larotrectinib toxicity and liver tests; reduce the larotrectinib dose if adverse effects occur.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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