Drug interactions
Larotrectinib + Nifedipine
Severity: Minor
Larotrectinib and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and weak inhibitor, so it may modestly raise exposure to sensitive CYP3A4 substrates such as nifedipine. This could increase hypotension, flushing or peripheral edema.
What this interaction means in plain words
Larotrectinib and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Nifedipine belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4-mediated nifedipine metabolism.
What to do
Monitor blood pressure and edema after starting larotrectinib, and lower the nifedipine dose if hypotension or adverse effects develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Nifedipine?
MediHelp rates the interaction as minor. Larotrectinib and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and weak inhibitor, so it may modestly raise exposure to sensitive CYP3A4 substrates such as nifedipine. This could increase hypotension, flushing or peripheral edema.
How serious is the interaction between Larotrectinib and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema after starting larotrectinib, and lower the nifedipine dose if hypotension or adverse effects develop.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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