Drug interactions
Larotrectinib + Nilotinib
Severity: Moderate
Larotrectinib and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and may increase larotrectinib exposure, potentially raising adverse effects such as hepatotoxicity, dizziness and neurotoxicity.
What this interaction means in plain words
Larotrectinib and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Larotrectinib belongs to Oncology; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibits CYP3A4, reducing larotrectinib metabolism.
What to do
Monitor liver enzymes and neurologic symptoms, and reduce the larotrectinib dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Nilotinib?
MediHelp rates the interaction as moderate. Larotrectinib and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and may increase larotrectinib exposure, potentially raising adverse effects such as hepatotoxicity, dizziness and neurotoxicity.
How serious is the interaction between Larotrectinib and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and neurologic symptoms, and reduce the larotrectinib dose if adverse effects occur.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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