Drug interactions
Larotrectinib + Pazopanib
Severity: Minor
Larotrectinib and Pazopanib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and a weak inhibitor, so it may slightly raise pazopanib levels. The clinical impact is probably small.
What this interaction means in plain words
Larotrectinib and Pazopanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Pazopanib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4 by larotrectinib.
What to do
Monitor for pazopanib adverse effects such as liver enzyme elevation and hypertension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Pazopanib?
MediHelp rates the interaction as minor. Larotrectinib and Pazopanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and a weak inhibitor, so it may slightly raise pazopanib levels. The clinical impact is probably small.
How serious is the interaction between Larotrectinib and Pazopanib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pazopanib adverse effects such as liver enzyme elevation and hypertension.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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