Drug interactions
Larotrectinib + Praziquantel
Severity: Minor
Larotrectinib and Praziquantel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with weak in vitro inhibitory activity, so an effect on praziquantel is uncertain and likely small. Any increase in praziquantel exposure would be expected to be brief given its short dosing course.
What this interaction means in plain words
Larotrectinib and Praziquantel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Praziquantel belongs to Anti Parasitic.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib; the mechanism is not firmly established.
What to do
No dose change is needed. Monitor tolerability of praziquantel such as dizziness and drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Praziquantel?
MediHelp rates the interaction as minor. Larotrectinib and Praziquantel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with weak in vitro inhibitory activity, so an effect on praziquantel is uncertain and likely small. Any increase in praziquantel exposure would be expected to be brief given its short dosing course.
How serious is the interaction between Larotrectinib and Praziquantel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor tolerability of praziquantel such as dizziness and drowsiness.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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