Drug interactions
Larotrectinib + Quinine
Severity: Minor
Larotrectinib and Quinine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with possible weak inhibitory effects, and an effect on quinine levels is only theoretical. Any increase would likely be small.
What this interaction means in plain words
Larotrectinib and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Quinine belongs to Anti Parasitic.
Why it happens
Possible weak CYP3A4 inhibition; not well established.
What to do
Monitor for quinine adverse effects such as tinnitus and palpitations; no empirical dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Quinine?
MediHelp rates the interaction as minor. Larotrectinib and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with possible weak inhibitory effects, and an effect on quinine levels is only theoretical. Any increase would likely be small.
How serious is the interaction between Larotrectinib and Quinine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine adverse effects such as tinnitus and palpitations; no empirical dose change is needed.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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