Drug interactions
Larotrectinib + Salmeterol
Severity: Minor
Larotrectinib and Salmeterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 inhibitor of limited potency and may slightly raise salmeterol exposure. The clinical effect is probably small with inhaled dosing.
What this interaction means in plain words
Larotrectinib and Salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Salmeterol belongs to Respiratory.
Why it happens
Weak inhibition of CYP3A4-mediated salmeterol metabolism.
What to do
Monitor for tremor, palpitations and tachycardia. No dose change is usually required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Salmeterol?
MediHelp rates the interaction as minor. Larotrectinib and Salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 inhibitor of limited potency and may slightly raise salmeterol exposure. The clinical effect is probably small with inhaled dosing.
How serious is the interaction between Larotrectinib and Salmeterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tremor, palpitations and tachycardia. No dose change is usually required.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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