Drug interactions
Larotrectinib + Sorafenib
Severity: Minor
Larotrectinib and Sorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and a weak CYP3A4 inhibitor, so it may slightly increase sorafenib exposure. The clinical impact is likely limited.
What this interaction means in plain words
Larotrectinib and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Sorafenib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by larotrectinib reduces sorafenib metabolism.
What to do
No routine dose change is needed. Monitor tolerability of sorafenib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sorafenib
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Sorafenib?
MediHelp rates the interaction as minor. Larotrectinib and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and a weak CYP3A4 inhibitor, so it may slightly increase sorafenib exposure. The clinical impact is likely limited.
How serious is the interaction between Larotrectinib and Sorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor tolerability of sorafenib.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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