Drug interactions
Larotrectinib + Tadalafil
Severity: Minor
Larotrectinib and Tadalafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with weak inhibitory potential, and a small rise in tadalafil exposure is theoretically possible. Clinical impact is probably minimal.
What this interaction means in plain words
Larotrectinib and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Tadalafil belongs to Genitourinary.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib; the mechanism is not well established.
What to do
No dose change is routinely needed; monitor for tadalafil adverse effects such as hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Tadalafil?
MediHelp rates the interaction as minor. Larotrectinib and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with weak inhibitory potential, and a small rise in tadalafil exposure is theoretically possible. Clinical impact is probably minimal.
How serious is the interaction between Larotrectinib and Tadalafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor for tadalafil adverse effects such as hypotension.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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