Drug interactions
Larotrectinib + Tolterodine
Severity: Minor
Larotrectinib and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and a weak CYP3A4 inhibitor, so it may slightly raise tolterodine exposure. The effect is likely small given the CYP2D6 pathway.
What this interaction means in plain words
Larotrectinib and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Tolterodine belongs to Genitourinary.
Why it happens
Weak inhibition of CYP3A4-mediated tolterodine metabolism by larotrectinib.
What to do
No routine adjustment is needed; monitor for anticholinergic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Tolterodine?
MediHelp rates the interaction as minor. Larotrectinib and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and a weak CYP3A4 inhibitor, so it may slightly raise tolterodine exposure. The effect is likely small given the CYP2D6 pathway.
How serious is the interaction between Larotrectinib and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for anticholinergic adverse effects.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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