Drug interactions
Ledipasvir-sofosbuvir + Oxcarbazepine
Severity: Major
Ledipasvir-sofosbuvir and Oxcarbazepine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine induces P-glycoprotein and may markedly lower sofosbuvir and ledipasvir concentrations. This risks loss of virologic response and treatment failure or resistance. Labeling recommends against coadministration.
What this interaction means in plain words
Ledipasvir-sofosbuvir and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ledipasvir-sofosbuvir belongs to Anti Virals; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Induction of intestinal P-glycoprotein reduces absorption of sofosbuvir and ledipasvir.
What to do
Avoid the combination; switch to a non-inducing anticonvulsant such as levetiracetam before starting HCV therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Ledipasvir-sofosbuvir with Oxcarbazepine?
MediHelp rates the interaction as major. Ledipasvir-sofosbuvir and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxcarbazepine induces P-glycoprotein and may markedly lower sofosbuvir and ledipasvir concentrations. This risks loss of virologic response and treatment failure or resistance. Labeling recommends against coadministration.
How serious is the interaction between Ledipasvir-sofosbuvir and Oxcarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; switch to a non-inducing anticonvulsant such as levetiracetam before starting HCV therapy.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
Full monographs, dosing and an interaction checker in the MediHelp app
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