Drug interactions
Ledipasvir / sofosbuvir + Regorafenib
Severity: Moderate
Ledipasvir / sofosbuvir and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit BCRP and raise concentrations of ledipasvir and sofosbuvir, which are BCRP substrates. Clinical consequences are probably limited but have not been well studied.
What this interaction means in plain words
Ledipasvir / sofosbuvir and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Regorafenib inhibits BCRP and P-gp mediated efflux of ledipasvir/sofosbuvir.
What to do
Monitor for antiviral adverse effects such as fatigue, headache and nausea. Check liver tests during combined therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Frequently asked questions
Can I take Ledipasvir / sofosbuvir with Regorafenib?
MediHelp rates the interaction as moderate. Ledipasvir / sofosbuvir and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib may inhibit BCRP and raise concentrations of ledipasvir and sofosbuvir, which are BCRP substrates. Clinical consequences are probably limited but have not been well studied.
How serious is the interaction between Ledipasvir / sofosbuvir and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for antiviral adverse effects such as fatigue, headache and nausea. Check liver tests during combined therapy.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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