Drug interactions
Ledipasvir-sofosbuvir + Safinamide
Severity: Minor
Ledipasvir-sofosbuvir and Safinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide may inhibit intestinal BCRP, and ledipasvir and sofosbuvir are BCRP substrates. Absorption of these antivirals could rise slightly, though the clinical impact is probably small.
What this interaction means in plain words
Ledipasvir-sofosbuvir and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ledipasvir-sofosbuvir belongs to Anti Virals; Safinamide belongs to Central Nervous System.
Why it happens
Inhibition of intestinal BCRP by safinamide may increase absorption of BCRP substrates.
What to do
No dose change is generally needed; monitor for adverse effects of the HCV regimen such as headache and fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Ledipasvir-sofosbuvir with Safinamide?
MediHelp rates the interaction as minor. Ledipasvir-sofosbuvir and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Safinamide may inhibit intestinal BCRP, and ledipasvir and sofosbuvir are BCRP substrates. Absorption of these antivirals could rise slightly, though the clinical impact is probably small.
How serious is the interaction between Ledipasvir-sofosbuvir and Safinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for adverse effects of the HCV regimen such as headache and fatigue.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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